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CASP2 and RIPK1 domain containing adaptor with death domain
Protein CRADD PDB 2o71.png
PDB rendering based on 2o71.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CRADD ; MRT34; RAIDD
External IDs OMIM603454 MGI1336168 HomoloGene2821 GeneCards: CRADD Gene
Species Human Mouse
Entrez 8738 12905
Ensembl ENSG00000169372 ENSMUSG00000045867
UniProt P78560 O88843
RefSeq (mRNA) NM_003805 NM_009950
RefSeq (protein) NP_003796 NP_034080
Location (UCSC) Chr 12:
94.07 – 94.29 Mb
Chr 10:
95.17 – 95.32 Mb
PubMed search [1] [2]

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.[1][2][3]


The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.[3]


CRADD has been shown to interact with RIPK1[1][2] and Caspase 2.[1][4][5]


  1. ^ a b c Duan H, Dixit VM (January 1997). "RAIDD is a new 'death' adaptor molecule". Nature 385 (6611): 86–9. doi:10.1038/385086a0. PMID 8985253. 
  2. ^ a b Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T et al. (March 1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP". Cancer Res. 57 (4): 615–9. PMID 9044836. 
  3. ^ a b "Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain". 
  4. ^ Tinel A, Tschopp J (May 2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321. 
  5. ^ Droin N, Beauchemin M, Solary E, Bertrand R (December 2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409. 

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