Category:Dihydrofolate reductase inhibitors

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These agents inhibit the enzyme dihydrofolate reductase, an important rate-limiting step in the de novo folate synthesis pathway. Methotrexate is a cancer chemotherapeutic agent, whilst trimethoprim is an antibiotic. The reason for this disparity, despite both being dihydrofolate reductase inhibitors, is that methotrexate has a selective affinity for mammalian dihydrofolate reductase, while trimethoprim has a selective affinity for the bacterial enzyme.

Subcategories

This category has the following 4 subcategories, out of 4 total.

Pages in category "Dihydrofolate reductase inhibitors"

The following 2 pages are in this category, out of 2 total. This list may not reflect recent changes (learn more).