Known for his deconstructive take on biographical subjects, Messina's most notable stage work is the critically acclaimed Off-Broadway play Mercury: The Afterlife and Times of a Rock God, a monodrama written and directed by Messina about Queen frontman Freddie Mercury, which starred Khalid Gonçalves and later, Amir Darvish.
Among Messina’s other biographical works, there is Cirque Jacqueline, about the life of Jacqueline Kennedy Onassis, which was written by and starred Andrea Reese, and The Accidental Pervert, an autobiographical one man show written and performed by Andrew Goffman and directed by Messina.
In 1999, Actor Found Dead, a one-act play written and directed by Messina about actor James Hayden (who Messina, as a child, had seen in American Buffalo), debuted at the John Houseman Studio Theatre in New York City. The play starred Khalid Gonçalves as Hayden, with Andrew I. Mones and David B. Martin. A screenplay based on Hayden's life was optioned in late 2007.
In 2007, Messina also directed the big budget musical Be My Love: The Mario Lanza Story, written by Richard Vetere, about the life of singer Mario Lanza, which was produced by Sonny Grosso and Phil Ramone. It premiered at The Tilles Center for the Performing Arts in Greenvale, NY.
Also in 2007, Messina's play Merging starring Jason Cerbone, Gina Ferranti and Ernest Mingione won Best Play in The Players' Theater's Shortened Attention Span Theater Festival in Greenwich Village. A film version of the play Merging was released in 2009.
Messina has directed the off-Broadway shows Rockaway Boulevard by Richard Vetere, The Accidental Pervert by Andrew Goffman, and Art Metrano's Accidental Comedy, as well as a staged reading of his own script Younger, starring Joe Piscopo.
Messina co-wrote the book My Father, My Don, about the life of Genovese Capo James "Jimmy Nap" Napoli and his son Tony Napoli, in collaboration with Tony Napoli. It was released by The Beckham Publications Group in fall 2008 and is currently available in Barnes & Noble and other major retail bookstores.
In May 2010, Messina directed and co-wrote (along with Vincent Gogliormella) the script Twas The Night Before a Brooklyn Christmas, starring Mario Cantone, Michael Rispoli and Robert Cuccioli, also at 45 Bleecker Street.
On March 29, 2012 - April 1, 2012, three of Messina's plays - Merging, Fugazy, and Sick Bastids - under the title The Tenement Plays, were performed at the 13th St Repertory Theater. Fugazy was directed by Gina Ferranti.
On September 22, 2013, The Abingdon Theatre hosted a special reading of three of Messina's plays: Fairies, Thompson Street, and Sinkhole, as part of a fundraiser for the theater. The cast included (in alphabetical order): Michael Barbieri, Anthony DeSando, Alfredo Diaz, Gina Ferranti, Nick Fondulis, Khalid Gonçalves, Steven LaChioma, Tom Alan Robbins, Scott Seidman, and Johnny Tammaro.
According to BroadwayWorld.com, Fairies was "so beloved by audiences" that The Abingdon Theatre decided to produce the show again, on December 17th, 2013. The entire original cast returned. 
On November 16, 2014, three new one-act plays by Messina were read at The Abingdon Theatre as part of their weekly Sunday Series. The plays, titled A Mooney for the Misbegotten, Fifteen Minutes of Shame, and Chubby & Glen, featured actors Jason Cerbone, Anthony DeSando, Mary Dimino, Gina Ferranti, Nick Fondulis, Valerie Smaldone, Johnny Tammaro, and Michael Townsend Wright.
The Abingdon Theatre will again be hosting a reading of Messina's latest one-act trilogy on March 22, 2015. Titled Three from the Neighborhood, the evening will mark the debut of Dewey, Phukum & Howe, The Neighborhood, and The Wreck. The cast will feature: Michael Barbieri, Rosie DeSanctis, Anthony DeSando, Alfredo Diaz, Mary Dimino, Nick Fondulis, Lynne Koplitz, Khalid Gonçalves, Ernest Mingione, Kyle C. Mumford, Craig Rivela, Jonathan Smith, Johnny Tammaro and Michael Townsend Wright. 
Messina will be debuting True East, an urban Twilight Zone-esque podcast series set in the Greenwich Village of the 1980's. The series is being produced by Hollywood veteran Craig Singer in conjunction with Sound Lounge's Marshall Grupp. It will be narrated by actor Ralph Macchio. 
Upcoming and announced projects
A Room of My Own
On September 20, 2010, a staged reading of Messina's semi-autobiographical play A Room of My Own, about an Italian-American family living in Greenwich Village in the late 1970s, was performed at The Theatre at 45 Bleecker Street in Greenwich Village with Ralph Macchio, Cantone, Lynne Koplitz, Gina Ferranti, Johnny Tammaro, John Barbieri, and Kendra Jain.
A Room of My Own is currently being developed for Broadway.
Messina is currently collaborating with Dion DiMucci on a musical about the singer's life called The Wanderer - the Life and Music of Dion, with Ted Kurdyla as executive producer. The first reading of the play was performed at the Triad Theater in New York City on October 13, 2011.
In a December 9, 2011 interview with The New York Times, Messina explained why he chose Dion's story as a subject: “The conflict was irresistible to me as a dramatist,” he said. “But what’s interesting about Dion is that he lived. In my other plays, you don’t have that ending where the guy overcame. Dion overcame.”
Messina is represented by Ron Gwiazda/Abrams Artists Agency (playwriting, screenwriting, directing).
Summary of Works
- Roman Candles (1995) - writer, director
- Mercury: The Afterlife and Times of a Rock God (1997) - writer, director
- Actor Found Dead (1999) - writer, director
- Rockaway Boulevard (2004) - director
- Cirque Jacqueline (2004–2008) - director
- The Accidental Pervert (2005–present) - director
- Younger (2006) - writer, director
- Two-Mur Humor (2007) - writer, director
- Be My Love: The Mario Lanza Story (2007) - director
- Accidental Comedy (2009) - director
- A Room of My Own (2009) - writer, director
- The Fatman Cometh (2011) - director
- The Wanderer - the Life and Music of Dion (2011) - writer, director
- Sick Bastids (2012) - writer
- Thompson Street (2013) - writer
- Lilac (2013) - writer
- Fugazy (2013) - writer
- An Honest Woman (2013) - writer, director
- Fairies (2013) - writer, director
- Thompson Street (2013) - writer, director
- Sinkhole (2013) - writer, director
- Chubby & Glen (2014) - writer, director
- Fifteen Minutes of Shame (2014) - writer, director
- A Mooney for the Misbegotten (2014) - writer, director
- Dewey, Phukum & Howe (2015) - writer, director
- The Neighborhood (2015) - writer, director
- The Wreck (2015) - writer, director
- Mercury: The Afterlife and Times of a Rock God - (2009) by Original Works Publishing.
- Three Plays by Charles Messina (Fugazy, Klepto and Merging) - (2011) by The Beckham Publications Group
- They're Just My Friends (2006) - co-writer
- Merging (2009) - screenwriter, director
- Spy (2011) - co-writer
- Choose (2011) - associate producer
- Thompson Street (2015) - writer
- My Father, My Don (2008) - co-author (published by The Beckham Publications Group) - Tony Nap Napoli
- True East (series) (2015) - writer, director
- Lefkowitz, David (24 Nov 1997). "Freddie Mercury To Rise Again, Off-B'way, Nov. 24". Playbill.com.
- Simonson, Robert (11 Jan 2004). "Bohemian Rhapsody: Freddy Mercury Play Begins Performances Off Broadway, Jan. 11". Playbill.com.
- McBride, Murdoch (18 Oct 1999). "Life Imitates Art in Actor Found Dead, Oct. 28 at John Houseman". Playbill.com.
- BWW News Desk. "'Two-mur Humor' to Premiere at FringeNYC in August". BroadwayWorld.com.
- "Richard Vetere Collection". Stony Brook University Special Collections & University Archives.
- "Merging (2009)". imdb.com. Retrieved 19 December 2011.
- Lenzi, Linda (May 12, 2010). "Photo Coverage: 'Twas the Night Before a Brooklyn Christmas' Industry Reading". BroadwayWorld.com.
- BWW News Desk (March 13, 2012). "Charles Messina's THE TENEMENT PLAYS Opens March 29". broadwayworld.com. Retrieved 27 March 2012.
- Black, Laurel (July 25, 2013). "Unconventional theater winds down season". The Paducah Sun. pp. 1C–2C. Retrieved 6 August 2013.
- BWW News Desk (August 15, 2013). "A LITTLE BIT OF THIS AND THAT Workshop to Benefit Abingdon Theatre, 9/22". BroadwayWorld.com. Retrieved 17 August 2013.
- BWW News Desk (October 29, 2013). "Abingdon to Stage Special Holiday Benefit Presentation of FAIRIES, 12/17". BroadwayWorld.com. Retrieved 30 October 2013.
- BWW News Desk (October 27, 2014). "Sunday Series at Abingdon to Present MOONLIGHT IN GREENWICH VILLAGE, 11/16". BroadwayWorld.com. Retrieved 3 November 2014.
- BWW News Desk (February 11, 2015). "Abingdon Theatre's Sunday Series to Present 3 FROM THE NEIGHBORHOOD". BroadwayWorld.com. Retrieved 11 February 2015.
- BWW News Desk (March 9, 2015). "Ralph Macchio to Narrate TRUE EAST Podcast Based on Charles Messina Plays". BroadwayWorld.com. Retrieved 9 March 2015.
- Lenzi, Linda (September 21, 2010). "Photo Coverage: Cantone, Macchio et al. in A ROOM OF MY OWN". BroadwayWorld.com.
- Gans, Andrew (November 8, 2012). "Mario Cantone, Rachel Dratch, Zach Galligan Set for Reading of A Room of My Own". Playbill.com. Retrieved 20 November 2012.
- Bowling, Suzanna (October 19, 2011). "The New Musical About The Life of Dion "The Wanderer" Wows Producers". The Times Square Chronicle.
- Gonzalez, David (December 9, 2011). "A Wanderer, the Singer Dion Returns to the Bronx". The New York Times. Retrieved 19 December 2011.
- "Charles Messina (II)". IMDb.com. Retrieved 19 December 2011.
- Charles Messina's official site
- NahNotOutsideMyHouse! Productions, Messina's production company
- Charles Messina at the Internet Movie Database