He was born in Dresden and died in London. He apprenticed his father and also studied painting. In 1706 he came to London to work at Charles Boit's studio, and when Boit left for France eight years later Zincke inherited many of his fashionable clients. He went on to become the most successful enamel painter of his era.
Suffering from poor eyesight in the later 1740s, he passed on his business to James Deacon.