The video plays as a mini soap opera depicting a man who goes home and finds out his woman has been cheating on him with another man. The song is taken to another level during the breakdown of the song, where the two men, Mr. Biggs and Kelly, meet once again after their previous battle on Kelly's 1996 single, "Down Low". In the middle of the second verse, Ron Isley goes down memory lane after saying "The down low happened to me all over again". In the video, there is also a brief clip of the "Down Low (Nobody Has To Know)" video, shown of Mr. Biggs beating R. Kelly with a sledgehammer.
"Contagious" rose to #19 on the pop singles chart and #3 on the R&B singles chart and made the Isleys the first band to score a hit in six consecutive decades on Billboard's Hot 100. The breakthrough helped their 2001 album Eternal go double platinum.