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Symbols CDSN ; D6S586E; HTSS; HTSS1; HYPT2; PSS; S
External IDs OMIM602593 MGI3505689 HomoloGene48005 GeneCards: CDSN Gene
RNA expression pattern
PBB GE CDSN 206192 at tn.png
PBB GE CDSN 206193 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1041 386463
Ensembl ENSG00000137197 ENSMUSG00000039518
UniProt Q15517 Q7TPC1
RefSeq (mRNA) NM_001264 NM_001008424
RefSeq (protein) NP_001255 NP_001008424
Location (UCSC) Chr 6:
31.08 – 31.09 Mb
Chr 17:
35.55 – 35.56 Mb
PubMed search [1] [2]

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.[1][2][3]

This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.[3]

See also[edit]


  1. ^ Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998). "Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes". J Biol Chem 272 (50): 31770–6. doi:10.1074/jbc.272.50.31770. PMID 9395522. 
  2. ^ Zhou Y, Chaplin DD (Nov 1993). "Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation". Proc Natl Acad Sci U S A 90 (20): 9470–4. doi:10.1073/pnas.90.20.9470. PMC 47590. PMID 8415725. 
  3. ^ a b "Entrez Gene: CDSN corneodesmosin". 

Further reading[edit]