The Cotard delusion, Cotard's syndrome, or Walking Corpse Syndrome is a rare mental disorder in which people hold a delusional belief that they are dead (either figuratively or literally), do not exist, are putrefying, or have lost their blood or internal organs. In rare instances, it can include delusions of immortality.
The syndrome is named after Jules Cotard (1840–1889), a French neurologist who first described the condition, which he called le délire de négation ("negation delirium"), in a lecture in Paris in 1880. He described the syndrome as having degrees of severity that range from mild to severe. Despair and self-loathing characterize a mild state. Severe state is characterized by intense delusions and chronic depression.
In one of his lectures, Cotard described a patient with the pseudonym of Mademoiselle X, who denied the existence of several parts of her body and her need to eat. Later she believed she was eternally damned and could no longer die a natural death. She later died of starvation.
Signs and symptoms 
The central symptom in Cotard's syndrome is the delusion of negation. Those who suffer from this illness often deny that they exist or that a certain portion of their body exists. Cotard's syndrome has been found to have three distinct stages. In the first stage – Germination – patients exhibit psychotic depression and hypochondriacal symptoms. The second stage – Blooming – is characterized by the full blown development of the syndrome and the delusions of negation. The third stage – Chronic – is characterized by severe delusions and chronic depression.
People with the Cotard Delusion often become withdrawn from others and they tend to neglect their own hygiene and well-being. The delusion makes it impossible for patients to make sense of reality, which results in an extremely distorted view of the world. This delusion is often found in psychotic patients suffering from schizophrenia. While Cotard's Syndrome doesn't necessitate hallucinations, the strong delusions are comparable to those found in schizophrenic patients.
The novel, "Maître Mussard's Bequest" ("Das Vermächtnis des Maître Mussard") by German author Patrick Süskind, describes a strange character, Maître Mussard, whom we can see, through his own writings, become psychosomatically paralyzed (similar to rigor mortis) as a result of a severe case of Cotard delusion.
Distorted reality 
[The patient's] symptoms occurred in the context of more general feelings of unreality and being dead. In January 1990, after his discharge from hospital in Edinburgh, his mother took him to South Africa. He was convinced that he had been taken to hell (which was confirmed by the heat), and that he had died of septicaemia (which had been a risk early in his recovery), or perhaps from AIDS (he had read a story in The Scotsman about someone with AIDS who died from septicaemia), or from an overdose of a yellow fever injection. He thought he had "borrowed my mother's spirit to show me round hell", and that she was asleep in Scotland.
An example of the distorted reality that results from Cotard Syndrome was described in a study of a 14-year-old patient with epilepsy. The child psychiatry OPD he was brought to described his history of expressing themes of death, being sad all the time, decreased play activity, social withdrawal, and disturbed biological function. He would have episodes about twice a year that lasted three weeks to three months at a time. In each episode, the child would say that everyone is dead, including trees. He would also describe himself as being a dead body. He warned that the world would be destroyed within a few hours. He showed no reaction to pleasurable stimuli and showed no interest in any activities.
The underlying psychopathology and neurophysiology of Cotard's Syndrome may be related to other problems involving delusional misidentification. Neurologically, Cotard's is thought to be related to the Capgras delusion, and both are thought to result from a disconnect between the brain areas that recognize faces (fusiform face areas) and the areas that associate emotions with that recognition (the amygdala and other limbic structures). This disconnection creates a sense that the observed face is not the person's it purports to be, and therefore lacks the familiarity that should be associated with it. The disconnect results in a feeling of derealization. If it is the face of a person known to the sufferer, it is experienced as an impostor's (Capgras); if the sufferer sees their own face they may feel no association between it and their sense of self, resulting in a sense that they do not exist.
Literature shows that Cotard's is associated with lesions in the parietal lobe. Patients with Cotard's generally have more brain atrophy than control groups and more median frontal lobe atrophy in particular.
Cotard's syndrome is encountered primarily in psychoses such as schizophrenia. It can arise in the context of neurological or mental illness and is particularly associated with depression and derealization. It has even been described in migraine.
Cotard delusion has also been the result of adverse drug reactions to (val)acyclovir. The symptoms were associated with high serum concentrations of CMMG, the principal metabolite of acyclovir. Patients with impaired renal function seem to be at risk even after dose reduction; in the cited case, haemodialysis cured the delusions in a few hours and it is suggested that this mental state may not always be a cause for psychiatric hospitalization.
Research shows that culture has an impact on the biographical experiences expressed by patients who suffer from Cotard's. This finding supports Bering's view of a cognitive system dedicated to forming illusory representations of immortality. Mainstream thought is that these illusory representations of immortality and other delusions evolved in response to sociological pressures.
There are several reports of successful pharmacological treatment. Monotherapeutic and combination strategies are both reported. Antidepressants, antipsychotics and mood stabilisers are used. Many report positive effect with electroconvulsive therapy, mostly in combination with pharmacotherapy.
See also 
- Berrios G.E. and Luque R. (1995) Cotard's delusion or syndrome?. Comprehensive Psychiatry 36: 218-223
- Berrios G.E. and Luque R. (1995) Cotard Syndrome: clinical analysis of 100 cases. Acta Psychiatrica Scandinavica 91: 185-188
- Cotard's syndrome at Who Named It?
- Berrios G.E. & Luque R. (1999) Cotard's 'On hypochondriacal delusions in a severe form of anxious melancholia'. History of Psychiatry 10: 269-278.
- Provider: John Wiley & Sons, Ltd Content:text/plain; charset="UTF-8" TY - JOUR AU - Yarnada, K. AU - Katsuragi, S. AU - Fujii, I. TI - A case study of Cotard's syndrome: stages and diagnosis JO - Acta Psychiatrica Scandinavica VL - 100 IS - 5 PB - Blackwell Publishing Ltd SN - 1600-0447 UR - http://dx.doi.org/10.1111/j.1600-0447.1999.tb10884.x DO - 10.1111/j.1600-0447.1999.tb10884.x SP - 396 EP - 398 KW - Cotard's syndrome KW - depression KW - electroconvulsive therapy PY - 1999 ER -
- Young, A. W., Robertson, I. H., Hellawell, D. J., de, P. K. W., & Pentland, B. (January 01, 1992). Cotard delusion after brain injury. Psychological Medicine, 22, 3, 799-804.
- Young, A.W. & Leafhead, K.M. (1996). Betwixt Life and Death: Case Studies of the Cotard Delusion (in P.W. Halligan & J.C. Marshall. (eds.) Method in Madness: Case studies in Cognitive Neuropsychiatry). Hove: Psychology Press. p. 155.
- Mendhekar, D. N., & Gupta, N. (January 01, 2005). Recurrent postictal depression with Cotard delusion. Indian Journal of Pediatrics, 72, 6, 529-31.
- Pearn, J. & Gardner-Thorpe, C (May 14, 2002). "Jules Cotard (1840-1889) His life and the unique syndrome that bears his name". Neurology (abstractPMID 12011289.) 58 (9): 1400–3. More than one of
- TY - JOUR T1 - Brain atrophy and interhemispheric fissure enlargement in Cotard's syndrome. AU - Joseph,AB AU - O'Leary,DH PY - 1986/10/ JF - The Journal of clinical psychiatry JO - J Clin Psychiatry IS - 10 VL - 47 N1 - Case Reports, KW - Adolescent KW - Adult KW - Atrophy KW - Brain KW - Death KW - Delusions KW - Female KW - Frontal Lobe KW - Humans KW - Male KW - Middle Aged KW - Tomography, X-Ray Computed SP - 518-20 UR - http://ukpmc.ac.uk/abstract/MED/3759917 N2 - The hallmark of Cotard's syndrome is the delusion of being dead. The literature indicates that it is often associated with parietal lobe lesions. This association was investigated by blindly comparing the computed tomographic scans of eight patients who had Cotard's syndrome (one of whom is described) with those of eight controls matched as closely as possible for age, sex, race, and principal psychiatric diagnosis. Two trends emerged. Compared with controls, patients with Cotard's syndrome had more brain atrophy in general and more median frontal lobe atrophy in particular. Parietal disease did not discriminate between the index and control groups. Cotard's syndrome may be associated with multifocal brain atrophy and medial frontal lobe disease. ER -
- Anders Helldén, Ingegerd Odar-Cederlöf, Kajsa Larsson, Ingela Fehrman-Ekholm,Thomas Lindén (Dec, 2007). "Death delusion" (Journal Article). BMJ 335 (7633): 1305–1305. doi:10.1136/bmj.39408.393137.BE. PMC 2151143. PMID 18156240. More than one of
- David Cohen and Angèle Consoli (2006). Production of supernatural beliefs during Cotard's syndrome, a rare psychotic depression. Behavioral and Brain Sciences, 29 , pp 468-470 doi:10.1017/S0140525X06299102
- Debruyne H., Portzky M., Van den Eynde F., Audenaert K. (June 2010). "Cotard's syndrome: a review.". Current psychiatric reports (review articlePMID 19470281.) 11 (3): 197–202. More than one of