DDT (gene)

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D-dopachrome tautomerase
Protein DDT PDB 1dpt.png
PDB rendering based on 1dpt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DDT ; DDCT
External IDs OMIM602750 MGI1298381 HomoloGene1038 GeneCards: DDT Gene
EC number
RNA expression pattern
PBB GE DDT 202929 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1652 13202
Ensembl ENSG00000099977 ENSMUSG00000001666
UniProt P30046 O35215
RefSeq (mRNA) NM_001084392 NM_010027
RefSeq (protein) NP_001077861 NP_034157
Location (UCSC) Chr 22:
24.31 – 24.32 Mb
Chr 10:
75.77 – 75.77 Mb
PubMed search [1] [2]

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.[1][2][3]

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.[3]

See also[edit]


  1. ^ Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844. 
  2. ^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3): 617–23. PMC 1219731. PMID 9729470. 
  3. ^ a b "Entrez Gene: DDT D-dopachrome tautomerase". 

Further reading[edit]