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DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Protein DDX41 PDB 2p6n.png
PDB rendering based on 2p6n.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DDX41 ; ABS
External IDs OMIM608170 MGI1920185 HomoloGene9431 GeneCards: DDX41 Gene
EC number
RNA expression pattern
PBB GE DDX41 217840 at tn.png
More reference expression data
Species Human Mouse
Entrez 51428 72935
Ensembl ENSG00000183258 ENSMUSG00000021494
UniProt Q9UJV9 Q91VN6
RefSeq (mRNA) NM_016222 NM_134059
RefSeq (protein) NP_057306 NP_598820
Location (UCSC) Chr 5:
176.94 – 176.94 Mb
Chr 13:
55.53 – 55.54 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.[2]


  1. ^ Irion U, Leptin M (Feb 2000). "Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt". Curr Biol 9 (23): 1373–81. doi:10.1016/S0960-9822(00)80082-2. PMID 10607561. 
  2. ^ a b "Entrez Gene: DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41". 

Further reading[edit]