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Diacylglycerol kinase, delta 130kDa
Protein DGKD PDB 1r79.png
PDB rendering based on 1r79.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DGKD ; DGKdelta; dgkd-2
External IDs OMIM601826 HomoloGene100054 ChEMBL: 1075120 GeneCards: DGKD Gene
EC number
RNA expression pattern
PBB GE DGKD 208072 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8527 227333
Ensembl ENSG00000077044 ENSMUSG00000070738
UniProt Q16760 E9PUQ8
RefSeq (mRNA) NM_003648 NM_177646
RefSeq (protein) NP_003639 NP_808314
Location (UCSC) Chr 2:
234.26 – 234.38 Mb
Chr 1:
87.85 – 87.94 Mb
PubMed search [1] [2]

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.[1][2][3]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[3]


  1. ^ Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538. 
  2. ^ Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723. 
  3. ^ a b "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa". 

Further reading[edit]