DYNLL2

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Dynein, light chain, LC8-type 2
Protein DYNLL2 PDB 1cmi.png
PDB rendering based on 1cmi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DYNLL2 ; DNCL1B; Dlc2; RSPH22
External IDs OMIM608942 MGI1915347 HomoloGene115597 GeneCards: DYNLL2 Gene
RNA expression pattern
PBB GE DYNLL2 gnf1h10414 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 140735 68097
Ensembl ENSG00000121083 ENSMUSG00000020483
UniProt Q96FJ2 Q9D0M5
RefSeq (mRNA) NM_080677 NM_001168471
RefSeq (protein) NP_542408 NP_001161943
Location (UCSC) Chr 17:
56.16 – 56.17 Mb
Chr 11:
87.98 – 87.99 Mb
PubMed search [1] [2]

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.[1][2]


Interactions[edit]

DYNLL2 has been shown to interact with DLG4,[3] DLGAP1,[3] MYO5A[3][4] and BMF.[4][5]

References[edit]

  1. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. 
  2. ^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2". 
  3. ^ a b c Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. (UNITED STATES) 20 (12): 4524–34. ISSN 0270-6474. PMID 10844022. 
  4. ^ a b Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science (United States) 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. 
  5. ^ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217. 

Further reading[edit]

DYNLL2 associations with risk for generalized anxiety disorder: Donner et al. An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders. Biological Psychiatry, 2008; 64 (8): 672 doi:10.1016/j.biopsych.2008.06.002