EBAG9

Estrogen receptor binding site associated, antigen, 9
Identifiers
Symbols	EBAG9; EB9; PDAF; RCAS1
External IDs	OMIM: 605772 MGI: 1859920 HomoloGene: 3107 GeneCards: EBAG9 Gene
Gene Ontology Molecular function • apoptotic protease activator activity Cellular component • Golgi membrane • soluble fraction • Golgi apparatus • plasma membrane • focal adhesion • integral to membrane Biological process • regulation of cell growth • apoptosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9166	55960
Ensembl	ENSG00000147654	ENSMUSG00000022339
UniProt	O00559	Q0VET4
RefSeq (mRNA)	NM_004215.3	NM_019480.4
RefSeq (protein)	NP_004206.1	NP_062353.3
Location (UCSC)	Chr 8: 110.55 – 110.58 Mb	Chr 15: 44.45 – 44.47 Mb
PubMed search	[1]	[2]

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Watanabe T, Inoue S, Hiroi H et al (1998). "Isolation of Estrogen-Responsive Genes with a CpG Island Library". Mol. Cell. Biol. 18 (1): 442–9. PMC 121513. PMID 9418891. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121513. 
• Nakashima M, Sonoda K, Watanabe T (1999). "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1". Nat. Med. 5 (8): 938–42. doi:10.1038/11383. PMID 10426319. 
• Ikeda K, Sato M, Tsutsumi O et al (2000). "Promoter analysis and chromosomal mapping of human EBAG9 gene". Biochem. Biophys. Res. Commun. 273 (2): 654–60. doi:10.1006/bbrc.2000.2920. PMID 10873660. 
• Ohshima K, Nakashima M, Sonoda K et al (2001). "Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege". Clin. Exp. Immunol. 123 (3): 481–6. doi:10.1046/j.1365-2249.2001.01461.x. PMC 1906005. PMID 11298137. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1906005. 
• Matsushima T, Nakashima M, Oshima K et al (2001). "Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells". Blood 98 (2): 313–21. doi:10.1182/blood.V98.2.313. PMID 11435298. 
• Tsuneizumi M, Emi M, Nagai H et al (2002). "Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers". Clin. Cancer Res. 7 (11): 3526–32. PMID 11705872. 
• Umeoka K, Sanno N, Oyama K et al (2002). "Immunohistochemical analysis of RCAS1 in human pituitary adenomas". Mod. Pathol. 14 (12): 1232–6. doi:10.1038/modpathol.3880467. PMID 11743045. 
• Hiraoka K, Hida Y, Miyamoto M et al (2002). "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker". Int. J. Cancer 99 (3): 418–23. doi:10.1002/ijc.10381. PMID 11992411. 
• Rousseau J, Têtu B, Caron D et al (2002). "RCAS1 is associated with ductal breast cancer progression". Biochem. Biophys. Res. Commun. 293 (5): 1544–9. doi:10.1016/S0006-291X(02)00401-1. PMID 12054692. 
• Oizumi S, Yamazaki K, Nakashima M et al (2002). "RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung". Oncology 62 (4): 333–9. doi:10.1159/000065065. PMID 12138241. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Engelsberg A, Hermosilla R, Karsten U et al (2003). "The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens". J. Biol. Chem. 278 (25): 22998–3007. doi:10.1074/jbc.M301361200. PMID 12672804. 
• Abe Y, Ohshima K, Nakashima M et al (2003). "Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis". Int. J. Hematol. 77 (4): 359–63. doi:10.1007/BF02982644. PMID 12774924. 
• Takahashi S, Urano T, Tsuchiya F et al (2003). "EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer". Int. J. Cancer 106 (3): 310–5. doi:10.1002/ijc.11205. PMID 12845666. 
• Sonoda K, Miyamoto S, Hirakawa T et al (2003). "Association between RCAS1 expression and clinical outcome in uterine endometrial cancer". Br. J. Cancer 89 (3): 546–51. doi:10.1038/sj.bjc.6601126. PMC 2394364. PMID 12888828. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2394364. 
• Leelawat K, Watanabe T, Nakajima M et al (2003). "Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer". J. Clin. Pathol. 56 (10): 764–8. doi:10.1136/jcp.56.10.764. PMC 1770069. PMID 14514780. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1770069. 
• Ikeguchi M, Ohoro S, Maeda Y et al (2004). "Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma". Oncol. Rep. 10 (6): 1891–4. PMID 14534714. 
• Ikeguchi M, Hirooka Y, Kaibara N (2004). "Gene and protein expression of RCAS1 in hepatocellular carcinoma". Anticancer Res. 23 (6D): 4967–71. PMID 14981953. 
• Brill LM, Salomon AR, Ficarro SB et al (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.