Endothelial activation

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Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.[1] It is also implicated in the formation of deep vein thrombosis.[2] As a result of activation, enthothelium releases Weibel–Palade bodies.[3]

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  1. ^ Alom-Ruiz SP, Anilkumar N, Shah AM (2008). "Reactive oxygen species and endothelial activation". Antioxid Redox Signal 10 (6): 1089–100. doi:10.1089/ars.2007.2007. PMID 18315494. 
  2. ^ Bovill EG, van der Vliet A (2011). "Venous valvular stasis-associated hypoxia and thrombosis: what is the link?". Annu Rev Physiol 73: 527–45. doi:10.1146/annurev-physiol-012110-142305. PMID 21034220. 
  3. ^ López JA, Chen J (2009). "Pathophysiology of venous thrombosis". Thromb Res 123 (Suppl 4): S30–4. doi:10.1016/S0049-3848(09)70140-9. PMID 19303501.