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Fanconi anemia group G protein is a protein that in humans is encoded by the FANCGgene.[5][6][7]
Function
FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The FANCG gene is responsible for complementation group G.[7]
^Léveillé F, Blom E, Medhurst AL, Bier P, Laghmani el H, Johnson M, Rooimans MA, Sobeck A, Waisfisz Q, Arwert F, Patel KJ, Hoatlin ME, Joenje H, de Winter JP (September 2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein". J. Biol. Chem. 279 (38): 39421–30. doi:10.1074/jbc.M407034200. PMID15262960.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^de Winter JP, van der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, Scheper RJ, Kruyt FA, Hoatlin ME, Joenje H (November 2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Hum. Mol. Genet. 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. PMID11063725.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ abGordon SM, Buchwald M (July 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems". Blood. 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. PMID12649160.
^ abcMedhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG (February 2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Hum. Mol. Genet. 10 (4): 423–9. doi:10.1093/hmg/10.4.423. PMID11157805.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Park SJ, Ciccone SL, Beck BD, Hwang B, Freie B, Clapp DW, Lee SH (July 2004). "Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins". J. Biol. Chem. 279 (29): 30053–9. doi:10.1074/jbc.M403527200. PMID15138265.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^van de Vrugt HJ, Koomen M, Berns MA, de Vries Y, Rooimans MA, van der Weel L, Blom E, de Groot J, Schepers RJ, Stone S, Hoatlin ME, Cheng NC, Joenje H, Arwert F (March 2002). "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg". Genes Cells. 7 (3): 333–42. doi:10.1046/j.1365-2443.2002.00518.x. PMID11918676.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Yagasaki H, Adachi D, Oda T, Garcia-Higuera I, Tetteh N, D'Andrea AD, Futaki M, Asano S, Yamashita T (December 2001). "A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA". Blood. 98 (13): 3650–7. doi:10.1182/blood.V98.13.3650. PMID11739169.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Huber PA, Medhurst AL, Youssoufian H, Mathew CG (February 2000). "Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis". Biochem. Biophys. Res. Commun. 268 (1): 73–7. doi:10.1006/bbrc.1999.2055. PMID10652215.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Kruyt FA, Abou-Zahr F, Mok H, Youssoufian H (November 1999). "Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain". J. Biol. Chem. 274 (48): 34212–8. doi:10.1074/jbc.274.48.34212. PMID10567393.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^Reuter T, Herterich S, Bernhard O, Hoehn H, Gross HJ (January 2000). "Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system". Blood. 95 (2): 719–20. PMID10627486.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Blom E, van de Vrugt HJ, de Vries Y, de Winter JP, Arwert F, Joenje H (January 2004). "Multiple TPR motifs characterize the Fanconi anemia FANCG protein". DNA Repair (Amst.). 3 (1): 77–84. doi:10.1016/j.dnarep.2003.09.007. PMID14697762.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Kuang Y, Garcia-Higuera I, Moran A, Mondoux M, Digweed M, D'Andrea AD (September 2000). "Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity". Blood. 96 (5): 1625–32. PMID10961856.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Thomashevski A, High AA, Drozd M, Shabanowitz J, Hunt DF, Grant PA, Kupfer GM (June 2004). "The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments". J. Biol. Chem. 279 (25): 26201–9. doi:10.1074/jbc.M400091200. PMID15082718.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W (October 2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID12973351.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ abTaniguchi T, D'Andrea AD (October 2002). "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC". Blood. 100 (7): 2457–62. doi:10.1182/blood-2002-03-0860. PMID12239156.
^Otsuki T, Young DB, Sasaki DT, Pando MP, Li J, Manning A, Hoekstra M, Hoatlin ME, Mercurio F, Liu JM (2002). "Fanconi anemia protein complex is a novel target of the IKK signalsome". J. Cell. Biochem. 86 (4): 613–23. doi:10.1002/jcb.10270. PMID12210728.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Garcia-Higuera I, Kuang Y, Denham J, D'Andrea AD (November 2000). "The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex". Blood. 96 (9): 3224–30. PMID11050007.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Kruyt FA, Abou-Zahr F, Mok H, Youssoufian H (1999). "Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain". J. Biol. Chem. 274 (48): 34212–8. doi:10.1074/jbc.274.48.34212. PMID10567393.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Reuter T; Herterich S; Bernhard O; et al. (2000). "Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system". Blood. 95 (2): 719–20. PMID10627486. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Huber PA, Medhurst AL, Youssoufian H, Mathew CG (2000). "Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis". Biochem. Biophys. Res. Commun. 268 (1): 73–7. doi:10.1006/bbrc.1999.2055. PMID10652215.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Yamada T; Tachibana A; Shimizu T; et al. (2000). "Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia". J. Hum. Genet. 45 (3): 159–66. doi:10.1007/s100380050203. PMID10807541. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kuang Y; Garcia-Higuera I; Moran A; et al. (2000). "Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity". Blood. 96 (5): 1625–32. PMID10961856. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Garcia-Higuera I, Kuang Y, Denham J, D'Andrea AD (2000). "The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex". Blood. 96 (9): 3224–30. PMID11050007.{{cite journal}}: CS1 maint: multiple names: authors list (link)
de Winter JP; van der Weel L; de Groot J; et al. (2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Hum. Mol. Genet. 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. PMID11063725. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Demuth I; Wlodarski M; Tipping AJ; et al. (2000). "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9". Eur. J. Hum. Genet. 8 (11): 861–8. doi:10.1038/sj.ejhg.5200552. PMID11093276. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Medhurst AL; Huber PA; Waisfisz Q; et al. (2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Hum. Mol. Genet. 10 (4): 423–9. doi:10.1093/hmg/10.4.423. PMID11157805. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
McMahon LW; Sangerman J; Goodman SR; et al. (2001). "Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links". Biochemistry. 40 (24): 7025–34. doi:10.1021/bi002917g. PMID11401546. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Yagasaki H; Adachi D; Oda T; et al. (2002). "A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA". Blood. 98 (13): 3650–7. doi:10.1182/blood.V98.13.3650. PMID11739169. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Futaki M; Igarashi T; Watanabe S; et al. (2002). "The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage". Carcinogenesis. 23 (1): 67–72. doi:10.1093/carcin/23.1.67. PMID11756225. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
van de Vrugt HJ (2002). "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg". Genes Cells. 7 (3): 333–42. doi:10.1046/j.1365-2443.2002.00518.x. PMID11918676. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
