English: Three different views of PR interacting with PI darunavir - Chain A colored pink with flap in coral and Chain B colored teal with the flap sky blue. Darunavir, the ligand colored sea-foam green, is held within a tunnel formed by the flap. The three views, front (a), back (b), and bottom (c) demonstrate how the ligand is enclosed and held stable by the flaps in the tunnel.
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