GALNT14

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UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
Identifiers
Symbols GALNT14 ; GALNT15; GalNac-T10; GalNac-T14
External IDs OMIM608225 MGI1918935 HomoloGene56997 GeneCards: GALNT14 Gene
EC number 2.4.1.41
RNA expression pattern
PBB GE GALNT14 219271 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79623 71685
Ensembl ENSG00000158089 ENSMUSG00000024064
UniProt Q96FL9 Q8BVG5
RefSeq (mRNA) NM_001253826 NM_027864
RefSeq (protein) NP_001240755 NP_082140
Location (UCSC) Chr 2:
31.13 – 31.38 Mb
Chr 17:
73.49 – 73.71 Mb
PubMed search [1] [2]

Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene.[1][2]

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM][2]

SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.[3] [4]

References[edit]

  1. ^ Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (Dec 2002). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochem Biophys Res Commun 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID 12507512. 
  2. ^ a b "Entrez Gene: GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)". 
  3. ^ Liang KH, Lin CC, Yeh CT (Jul 2011). "GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC.". Pharmacogenomics 12: 1061–73. doi:10.2217/pgs.11.43. PMID 21635146. 
  4. ^ Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL, Hung CF. (Mar 2014). "A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma.". Int J Cancer. 134: 1214–1224. doi:10.1002/ijc.28439. PMID 23959947. 

Further reading[edit]