GNL3

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Guanine nucleotide binding protein-like 3 (nucleolar)
Identifiers
Symbols GNL3 ; C77032; E2IG3; NNP47; NS
External IDs OMIM608011 MGI1353651 HomoloGene56670 GeneCards: GNL3 Gene
RNA expression pattern
PBB GE GNL3 217850 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26354 30877
Ensembl ENSG00000163938 ENSMUSG00000042354
UniProt Q9BVP2 Q8CI11
RefSeq (mRNA) NM_014366 NM_153547
RefSeq (protein) NP_055181 NP_705775
Location (UCSC) Chr 3:
52.72 – 52.73 Mb
Chr 14:
31.01 – 31.02 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein-like 3 also known as nucleostemin is a protein that in humans is encoded by the GNL3 gene.[1][2][3] It is found within the nucleolus that binds p53.[4] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[4] It is a marker for many stem cells and cancer cells.[5]


Interactions[edit]

GNL3 has been shown to interact with Mdm2[6] and P53.[2]

References[edit]

  1. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res 60 (21): 5977–83. PMID 11085516. 
  2. ^ a b Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630. 
  3. ^ "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)". 
  4. ^ a b Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 0-7817-7200-1. 
  5. ^ Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011. 
  6. ^ Dai, Mu-Shui; Sun Xiao-Xin; Lu Hua (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. (United States) 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907. 

Further reading[edit]