GRAP2

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GRB2-related adaptor protein 2
Protein GRAP2 PDB 1h3h.png
PDB rendering based on 1h3h.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GRAP2 ; GADS; GRAP-2; GRB2L; GRBLG; GRID; GRPL; GrbX; Grf40; Mona; P38
External IDs OMIM604518 MGI1333842 HomoloGene21007 GeneCards: GRAP2 Gene
RNA expression pattern
PBB GE GRAP2 208406 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9402 17444
Ensembl ENSG00000100351 ENSMUSG00000042351
UniProt O75791 O89100
RefSeq (mRNA) NM_001291824 NM_001289442
RefSeq (protein) NP_001278753 NP_001276371
Location (UCSC) Chr 22:
40.3 – 40.37 Mb
Chr 15:
80.62 – 80.65 Mb
PubMed search [1] [2]

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.[1][2][3]

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.[3]

Interactions[edit]

GRAP2 has been shown to interact with CD28,[4] STAMBP,[2][5] CCNDBP1,[6] Linker of activated T cells,[2][7] Lymphocyte cytosolic protein 2[2][4][5][7] and MAP4K1.[8]

References[edit]

  1. ^ Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (January 1999). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochem Biophys Res Commun 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555. 
  2. ^ a b c d Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (June 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". J Exp Med 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278. 
  3. ^ a b "Entrez Gene: GRAP2 GRB2-related adaptor protein 2". 
  4. ^ a b Ellis, J H; Ashman C; Burden M N; Kilpatrick K E; Morse M A; Hamblin P A (June 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". J. Immunol. (UNITED STATES) 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. ISSN 0022-1767. PMID 10820259. 
  5. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (July 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. (UNITED STATES) 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN 0021-9258. PMID 10801854. 
  7. ^ a b Liu, S K; Fang N; Koretzky G A; McGlade C J (January 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Curr. Biol. (ENGLAND) 9 (2): 67–75. doi:10.1016/S0960-9822(99)80017-7. ISSN 0960-9822. PMID 10021361. 
  8. ^ Ma, W; Xia C; Ling P; Qiu M; Luo Y; Tan T H; Liu M (March 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene (England) 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. ISSN 0950-9232. PMID 11313918. 

Further reading[edit]