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Hyaluronan binding protein 2
External IDs OMIM603924 MGI1196378 HomoloGene3050 GeneCards: HABP2 Gene
RNA expression pattern
PBB GE HABP2 206010 at tn.png
More reference expression data
Species Human Mouse
Entrez 3026 226243
Ensembl ENSG00000148702 ENSMUSG00000025075
UniProt Q14520 Q8K0D2
RefSeq (mRNA) NM_001177660 NM_146101
RefSeq (protein) NP_001171131 NP_666213
Location (UCSC) Chr 10:
115.31 – 115.35 Mb
Chr 19:
56.29 – 56.32 Mb
PubMed search [1] [2]

Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.[1][2][3]

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.[3]


  1. ^ Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M (Dec 1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem 119 (6): 1157–65. doi:10.1093/oxfordjournals.jbchem.a021362. PMID 8827452. 
  2. ^ Romisch J (Nov 2002). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol Chem 383 (7–8): 1119–24. doi:10.1515/BC.2002.121. PMID 12437095. 
  3. ^ a b "Entrez Gene: HABP2 hyaluronan binding protein 2". 

Further reading[edit]