HIST1H2BN

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Histone cluster 1, H2bn
Protein HIST1H2BN PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HIST1H2BN ; H2B/d; H2BFD
External IDs OMIM602801 HomoloGene135961 GeneCards: HIST1H2BN Gene
RNA expression pattern
PBB GE HIST1H2BN 207226 at tn.png
PBB GE HIST1H2BL 208579 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8341 319186
Ensembl ENSG00000233822 ENSMUSG00000096807
UniProt Q99877 P10854
RefSeq (mRNA) NM_003520 NM_178200
RefSeq (protein) NP_003511 NP_835507
Location (UCSC) Chr 6:
27.81 – 27.82 Mb
Chr 13:
21.72 – 21.72 Mb
PubMed search [1] [2]

Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[3]

References[edit]

  1. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BN histone cluster 1, H2bn". 

Further reading[edit]