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Histone cluster 2, H2be
Protein HIST2H2BE PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST2H2BE ; GL105; H2B; H2B.1; H2BFQ; H2BGL105; H2BQ
External IDs OMIM601831 MGI2448387 HomoloGene130120 GeneCards: HIST2H2BE Gene
RNA expression pattern
PBB GE HIST2H2BE 202708 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8349 68024
Ensembl ENSG00000184678 ENSMUSG00000018102
UniProt Q16778 Q6ZWY9
RefSeq (mRNA) NM_003528 NM_023422
RefSeq (protein) NP_003519 NP_075911
Location (UCSC) Chr 1:
149.86 – 149.86 Mb
Chr 13:
23.57 – 23.57 Mb
PubMed search [1] [2]

Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.[3]


  1. ^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem 50 (4): 374–85. doi:10.1002/jcb.240500406. PMID 1469070. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST2H2BE histone cluster 2, H2be". 

Further reading[edit]