Ham test

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The Ham test is a test used in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). The test involves placing red blood cells in mild acid; a positive result (increased RBC fragility) indicates PNH or Congenital dyserythropoietic anemia. [1] [2] This is now an obsolete test for diagnosing PNH due to its low sensitivity and specificity.[3]


  1. ^ Ham TH (1937). "Chronic haemolytic anaemia with paroxysmal nocturnal haemoglobinuria: study of the mechanism of haemolysis in relation to acid-base equilibrium". N Engl J Med 217 (23): 915–918. doi:10.1056/NEJM193712022172307. 
  2. ^ http://www.nlm.nih.gov/medlineplus/ency/article/003672.htm
  3. ^ "Paroxysmal Nocturnal Hemoglobinuria - PNH". ARUP.