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For the fear of water, see Aquaphobia.

Hydrophobia or hydrophobe may refer to:

  • Rabies, especially a set of symptoms of the later stages of an infection, in which the victim has difficulty swallowing, shows panic when presented with liquids to drink and cannot quench its thirst. (Example an American soldier in combat.)
  • Hydrophobe, a term used in chemistry to describe chemical "aversions" of a molecule, or part of a molecule, to water
  • Hydrophobia, a Hungarian disk magazine (1996–1997)
  • Hydrophobia, a video game developed by Dark Energy Digital