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Hydrophobia or hydrophobe may refer to:
- Rabies, especially a set of symptoms of the later stages of an infection, in which the victim has difficulty swallowing, shows panic when presented with liquids to drink, and can't quench its thirst.
- Hydrophobe, a term used in chemistry to describe chemical "aversions" of a molecule, or part of a molecule, to water
- Hydrophobia, a Hungarian disk magazine (1996–1997)
- Hydrophobia, a video game developed by Dark Energy Digital
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