Hydroxylysine
| Hydroxylysine | |
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(2S,5R)-2,6-Diamino-5-hydroxyhexanoic acid, (2S,5S)-2,6-Diamino-5-hydroxyhexanoic acid |
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Other names
5-Hydroxy-L-lysine, |
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| Identifiers | |
| CAS number | 28902-93-4  |
| PubChem | 3032849 |
| ChemSpider | 10613296 |
| UNII | 2GQB349IUB |
| MeSH | Hydroxylysine |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C6H14N2O3 |
| Molar mass | 162.187 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
5-Hydroxylysine is an amino acid with the molecular formula C6H14N2O3. It was first discovered in 1921 by Donald Van Slyke.[1] It is a hydroxy derivative of lysine. It is most widely known as a component of collagen.[2]
It is biosynthesized from lysine via oxidation by lysyl hydroxylase enzymes. The most common form is the (5R) stereoisomer found in collagen. However, JMJD6 has recently been shown to be a lysyl hydroxylase which modifies an RNA splicing factor producing the (5S) stereoisomer.
[edit] References
- ^ Van Slyke, DD.; Hiller, A. (Jul 1921). "An Unidentified Base among the Hydrolytic Products of Gelatin.". Proc Natl Acad Sci U S A 7 (7): 185–6. doi:10.1073/pnas.7.7.185. PMID 16586836.
- ^ Hydroxylysine at University of Oulu
