IHH (protein)

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For the Turkish Islamic relief organization, see IHH (Turkish NGO).
Indian hedgehog
Protein IHH PDB 1vhh.png
PDB rendering based on 1vhh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IHH ; BDA1; HHG2
External IDs OMIM600726 MGI96533 HomoloGene22586 GeneCards: IHH Gene
RNA expression pattern
PBB GE IHH 215420 at tn.png
More reference expression data
Species Human Mouse
Entrez 3549 16147
Ensembl ENSG00000163501 ENSMUSG00000006538
UniProt Q14623 P97812
RefSeq (mRNA) NM_002181 NM_010544
RefSeq (protein) NP_002172 NP_034674
Location (UCSC) Chr 2:
219.92 – 219.93 Mb
Chr 1:
74.95 – 74.95 Mb
PubMed search [1] [2]

Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene.[1][2][3]


The Indian hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and sonic hedgehog (SHH).[4] It is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification. It regulates its effects by feedback control of parathyroid hormone-related peptide (PTHrP).[5]


  1. ^ "Entrez Gene: IHH Indian hedgehog homolog (Drosophila)". 
  2. ^ Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746. 
  3. ^ van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP (March 2004). "Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation". Nat. Genet. 36 (3): 277–82. doi:10.1038/ng1304. PMID 14770182. 
  4. ^ Kumar S, Balczarek KA, Lai ZC (March 1996). "Evolution of the hedgehog gene family". Genetics 142 (3): 965–72. PMC 1207033. PMID 8849902. 
  5. ^ Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (August 1996). "Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein". Science 273 (5275): 613–22. doi:10.1126/science.273.5275.613. PMID 8662546. 

Further reading[edit]