IRS4

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Insulin receptor substrate 4
Identifiers
Symbols IRS4 ; IRS-4; PY160
External IDs OMIM300904 MGI1338009 HomoloGene136777 GeneCards: IRS4 Gene
RNA expression pattern
PBB GE IRS4 207403 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8471 16370
Ensembl ENSG00000133124 ENSMUSG00000054667
UniProt O14654 Q9Z0Y7
RefSeq (mRNA) NM_003604 NM_010572
RefSeq (protein) NP_003595 NP_034702
Location (UCSC) Chr X:
107.98 – 107.98 Mb
Chr X:
141.71 – 141.73 Mb
PubMed search [1] [2]

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.[1][2][3]

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.[3]

Interactions[edit]

IRS4 has been shown to interact with CRK[4][5] and NISCH.[6]

References[edit]

  1. ^ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155. 
  2. ^ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137. 
  3. ^ a b "Entrez Gene: IRS4 insulin receptor substrate 4". 
  4. ^ Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology (United States) 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748. 
  5. ^ Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction". J. Biol. Chem. (UNITED STATES) 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078. 
  6. ^ Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. (United States) 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194. 

Further reading[edit]