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Interstate 580 is the designation for several Interstate Highways in the United States, all of which are related to Interstate 80:
- Interstate 580 (California), a connector in the San Francisco Bay Area to Interstate 5
- Interstate 580 (Nevada), a spur connecting Reno, Nevada to Carson City, Nevada (also signed as U.S. Highway 395)
- Interstate 580 (Nebraska), now part of U.S. Highway 75 in Omaha, Nebraska
|This disambiguation page lists articles about roads and streets with the same name.
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