An intrathecal pump is a medical device used to deliver medications directly into the space between the spinal cord and the protective sheath surrounding the spinal cord. Medications such as baclofen, morphine, or ziconotide may be delivered in this manner to minimize the side effects often associated with the higher doses used in oral or intravenous delivery of these drugs.
People with spastic diplegia or other forms of spasticity, or people in intolerable pain, who cannot tolerate side effects of the higher-dose oral medications of the same medication type, are potential candidates for that medication being administered via an intrathecal pump.
The intrathecal pump consists of a metal pump which stores and delivers the medication, and a catheter which delivers the medication from the pump to the intrathecal space in the spine where the medication takes effect. Two types of pumps are available: a constant rate pump delivers the medication at a constant rate, and a programmable pump delivers the medication according to a rate determined by a computer program.
The implantable medical device requires a surgical procedure; a surgeon usually performs a trial intrathecal injection or implants a temporary intrathecal pump to determine if the medication works to begin with, and thus if a pump is appropriate. A permanent intrathecal pump is then implanted if the patient derives at least 50% improvement in his or her symptoms.
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- Penn, RD et al. (1989). "Intrathecal baclofen for severe spinal spasticity". New Engl J Med 320 (23): 1517–1521. doi:10.1056/NEJM198906083202303. PMID 2657424.