He was born in Verona. In 1750, he completed frescoes for the interior of Ca' Rezzonico, and in 1780 for the church of San Tomà. He also painted for the church of San Teonisto in Treviso, the Villa Contarini in Cinto Euganeo. He also helped decorate Villa Pisani at Stra. Other works were completed for Palazzo Balbi, Palazzo Boldù a San Felice, Palazzo Erizzo, and Palazzo Mocenigo Gambara.
Guarana is the last remaining heir of the Tiepolesque tradition. He was a founding member of the Venetian Academy of Arts, and is said to have studied under the then elder Sebastiano Ricci, then with Giovanni Battista Tiepolo. Among his most gratifying works is the wall frescoes at the concert hall of the Ospedaletto, Venice. By the time, he paints a Sacred heart of Jesus and Saints for the church of San Polo, his work would have been retardataire, a glimpse of a lapsing past.  His son, Vincenzo Guarana, born in 1742, was also a painter.
- Painting in Eighteenth century Venice. by Michael Levey. Page 69
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