His career record was 45 wins, 52 losses, 498 strikeouts and a 4.61 ERA. D'Amico enjoyed only one exceptional year, 2000, during which his ERA hovered around 2.00 for much of the season and he contended for the NL ERA title. Needing just a few innings to qualify for the title on his last start of the season, he surpassed the 162 inning minimum threshold, but in the process gave up enough runs to lose the title. D'Amico finished third, behind Kevin Brown and Randy Johnson.
D'Amico was never able to follow up that success, however, as he struggled with injuries for the Brewers in 2001, before ending his career with stints on the Mets, Pirates, and Indians. He led the National League in losses during the 2003 with the Pirates, and was released by the Indians in June 2004 after posting a 7.63 ERA in 7 starts for them.