KIF15

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Kinesin family member 15
Identifiers
Symbols KIF15 ; HKLP2; KNSL7; NY-BR-62
External IDs HomoloGene23210 GeneCards: KIF15 Gene
Orthologs
Species Human Mouse
Entrez 56992 209737
Ensembl ENSG00000163808 ENSMUSG00000036768
UniProt Q9NS87 Q6P9L6
RefSeq (mRNA) NM_020242 NM_010620
RefSeq (protein) NP_064627 NP_034750
Location (UCSC) Chr 3:
44.8 – 44.91 Mb
Chr 9:
122.95 – 123.02 Mb
PubMed search [1] [2]

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene.[1]

This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons.[1]

Function[edit]

KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth.[2] KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11.[3] KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner.[4][5]

Function in neurons[edit]

KIF15 restricts the movement of short microtubules into growing axons by generating forces on microtubules which counteract those generated by cytoplasmic dynein.[6][7] KIF15, together with KIF23 become enriched in dendrites as neurons mature to promote the transport of minus-end distal microtubules into nascent dendrites.[6]

Interactions[edit]

KIF15 has been shown to interact with TPX2. Both these dimers cooperate to slide along microtubules and maintain bipolar spindles.[8][9]

References[edit]

  1. ^ a b "Entrez Gene: Kinesin family member 15". 
  2. ^ Buster DW, Baird DH, Yu W, Solowska JM, Chauvière M, Mazurek A, Kress M, Baas PW (January 2003). "Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development". J. Neurocytol. 32 (1): 79–96. doi:10.1023/a:1027332432740. PMID 14618103. 
  3. ^ Vanneste D, Takagi M, Imamoto N, Vernos I (November 2009). "The role of Hklp2 in the stabilization and maintenance of spindle bipolarity". Curr. Biol. 19 (20): 1712–7. doi:10.1016/j.cub.2009.09.019. PMID 19818619. 
  4. ^ Florian S, Mayer TU (October 2011). "Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindles". Cell Cycle 10 (20): 3533–44. doi:10.4161/cc.10.20.17817. PMID 22024925. 
  5. ^ Dumont J (January 2012). "Bipolar disorder: kinesin-12 to the rescue". Cell Cycle 11 (2): 212–3. doi:10.4161/cc.11.2.18785. PMID 22214669. 
  6. ^ a b Lin S, Liu M, Mozgova OI, Yu W, Baas PW (October 2012). "Mitotic motors coregulate microtubule patterns in axons and dendrites". J. Neurosci. 32 (40): 14033–49. doi:10.1523/JNEUROSCI.3070-12.2012. PMC 3482493. PMID 23035110. 
  7. ^ Liu M, Nadar VC, Kozielski F, Kozlowska M, Yu W, Baas PW (November 2010). "Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching". J. Neurosci. 30 (44): 14896–906. doi:10.1523/JNEUROSCI.3739-10.2010. PMC 3064264. PMID 21048148. 
  8. ^ Tanenbaum ME, Macůrek L, Janssen A, Geers EF, Alvarez-Fernández M, Medema RH (November 2009). "Kif15 cooperates with eg5 to promote bipolar spindle assembly". Curr. Biol. 19 (20): 1703–11. doi:10.1016/j.cub.2009.08.027. PMID 19818618. 
  9. ^ Vanneste D, Ferreira V, Vernos I (October 2011). "Chromokinesins: localization-dependent functions and regulation during cell division". Biochem. Soc. Trans. 39 (5): 1154–60. doi:10.1042/BST0391154. PMID 21936781. 

Further reading[edit]

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