KLK15

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Kallikrein-related peptidase 15
Identifiers
Symbols KLK15 ; ACO; HSRNASPH
External IDs OMIM610601 MGI2447533 HomoloGene77571 ChEMBL: 2174 GeneCards: KLK15 Gene
RNA expression pattern
PBB GE KLK15 221462 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55554 317652
Ensembl ENSG00000174562 ENSMUSG00000055193
UniProt Q9H2R5 Q3B856
RefSeq (mRNA) NM_001277081 NM_174865
RefSeq (protein) NP_001264010 NP_777354
Location (UCSC) Chr 19:
51.33 – 51.34 Mb
Chr 7:
43.93 – 43.94 Mb
PubMed search [1] [2]

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.[5]

References[edit]

  1. ^ Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP (Feb 2001). "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". J Biol Chem 276 (1): 53–61. doi:10.1074/jbc.M005432200. PMID 11010966. 
  2. ^ Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, Biglia N, Abd Ellatif M, Diamandis EP (Nov 2002). "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br J Cancer 87 (11): 1294–300. doi:10.1038/sj.bjc.6600590. PMC 2408911. PMID 12439720. 
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  4. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  5. ^ a b "Entrez Gene: KLK15 kallikrein-related peptidase 15". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.081