The Keokuk Young Women's Christian Association Building in Keokuk, Iowa, United States is an historic building that was built in 1913. It was listed on the National Register of Historic Places in 2004. The building was home to the YWCA in Keokuk for nearly 50 years. The YMCA sat across the street until the building was demolished in 1975. The building served as a hub for social activities in the community. The building is representative of transitional architecture in the early 20th century.