The regiment has its origins in the field signal (later telegraphy) company raised in 1871. This unit then evolved and finally became Upplands regemente in 1974. That regiment was disbanded in 2006 but was replaced by Ledningsregementet which took the role that Upplands regemente previously had. The regiment was commanded by Lena Hallin, the first female regimental commander in Swedish history, until January 2011. The current regimental commander is air force colonel Thomas Nilsson.