MDX-1097
| Monoclonal antibody | |
|---|---|
| Type | ? |
| Clinical data | |
| Other names | IST-1097; KappaMab |
| Identifiers | |
| CAS Number | |
MDX-1097 (also called IST-1097 or KappaMab) is a monoclonal antibody therapy being assessed in Phase IIb clinical trials as a treatment for multiple myeloma, a type of white blood cell cancer.[1] It is a chimeric version of the mouse monoclonal antibody K-1-21.[2] MDX-1097 targets kappa free immunoglobulin light chains which are found on the surface of some kappa light chain-restricted myeloma cells.[3][4]
MDX-1097 was originally developed by scientists at Immune System Therapeutics Ltd.[4] In 2015, Haemalogix Pty Ltd acquired the rights to MDX-1097 and are now taking it through late stage clinical testing.[5][6]
References
- ^ "Australian New Zealand Clinical Trials Registry Number12616001164482".
- ^ Hutchinson AT, Alexova R, Bockhorni V, Ramsland PA, Jones DR, Jennings CV, Broady K, Edmundson AB, Raison RL (May 2011). "Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential". Molecular Immunology. 48 (9–10): 1245–52. doi:10.1016/j.molimm.2011.03.003. hdl:10453/18671. PMID 21466897.
- ^ Hutchinson AT, Ramsland PA, Jones DR, Agostino M, Lund ME, Jennings CV, Bockhorni V, Yuriev E, Edmundson AB, Raison RL (Oct 2010). "Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form". Journal of Immunology. 185 (7): 4179–88. doi:10.4049/jimmunol.1001956. PMID 20817866.
- ^ a b Hutchinson, A. T.; Jones, D. R.; Raison, R. L. (2015). "Preclinical and clinical development of an anti-kappa free light chain mAb for multiple myeloma". Molecular Immunology. 67 (2 Pt A): 89–94. doi:10.1016/j.molimm.2015.04.013. PMID 25964097.
- ^ "Immune System Therapeutics Circular to Creditors 25 May 2015" (PDF).
- ^ "Haemalogix Website - MDX-1097 Clinical Trials".
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