MEP1B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Meprin A, beta
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol MEP1B
External IDs OMIM600389 MGI96964 HomoloGene48382 GeneCards: MEP1B Gene
EC number 3.4.24.63
RNA expression pattern
PBB GE MEP1B 207251 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4225 17288
Ensembl ENSG00000141434 ENSMUSG00000024313
UniProt Q16820 Q61847
RefSeq (mRNA) NM_005925 NM_008586
RefSeq (protein) NP_005916 NP_032612
Location (UCSC) Chr 18:
29.77 – 29.8 Mb
Chr 18:
21.07 – 21.1 Mb
PubMed search [1] [2]

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.[1][2]

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A; MIM 600388) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. See MIM 600388 for further information on meprins.[supplied by OMIM][2]

References[edit]

  1. ^ Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936. 
  2. ^ a b "Entrez Gene: MEP1B meprin A, beta". 

Further reading[edit]