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Microsomal glutathione S-transferase 2
Symbols MGST2 ; GST2; MGST-II
External IDs OMIM601733 HomoloGene1811 ChEMBL: 1743185 GeneCards: MGST2 Gene
EC number
Species Human Mouse
Entrez 4258 211666
Ensembl ENSG00000085871 ENSMUSG00000074604
UniProt Q99735 n/a
RefSeq (mRNA) NM_001204366 NM_174995
RefSeq (protein) NP_001191295 NP_778160
Location (UCSC) Chr 4:
140.59 – 140.66 Mb
Chr 3:
51.66 – 51.68 Mb
PubMed search [1] [2]

Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.[1][2]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.[2]


  1. ^ Jakobsson PJ, Mancini JA, Ford-Hutchinson AW (Oct 1996). "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase". J Biol Chem 271 (36): 22203–10. doi:10.1074/jbc.271.36.22203. PMID 8703034. 
  2. ^ a b "Entrez Gene: MGST2 microsomal glutathione S-transferase 2". 

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