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MHC class I polypeptide-related sequence B
Protein MICB PDB 1je6.png
PDB rendering based on 1je6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MICB ; PERB11.2
External IDs OMIM602436 MGI2179988 HomoloGene88329 GeneCards: MICB Gene
RNA expression pattern
PBB GE MICB 206247 at tn.png
PBB GE MICA 205905 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4277 243864
Ensembl ENSG00000204516 ENSMUSG00000040987
UniProt Q29980 Q8HWE5
RefSeq (mRNA) NM_001289160 NM_153760
RefSeq (protein) NP_001276089 NP_715641
Location (UCSC) Chr 6:
31.46 – 31.48 Mb
Chr 7:
18.84 – 18.86 Mb
PubMed search [1] [2]

MHC class I polypeptide-related sequence B is a protein that in humans is encoded by the MICB gene.[1]

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of Natural killer cell, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides.[2]

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