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Makoto Furutani-Seiki

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Makoto Furutani-Seiki
NationalityJapanese
Other namesFuruya-Makoto Kiyoki
Alma materYamaguchi University, University of Tokyo
Known forMolecular Biology

Cell Biology Genetics Genomics Cancer Biology Mutation Gene Expression

Cloning
Scientific career
FieldsImmunology

Developmental Genetics Regenerative Medicine

Cancer
InstitutionsYamaguchi University

University of Tokyo Max Planck Institute, Germany University of Freiburg, Germany Kumamoto University

University of Bath, UK
Doctoral advisorTomio Tada[1]
Websitehttps://researchmap.jp/7000021820?lang=en

Makoto Furutani-Seiki is Director of UK Research Centre for Regenerative Medicine and Biochemistry Research Division, University of Bath, UK.[2]

Education

Furutani-Seiki was educated at the Yamaguchi University[3] School of Medicine, Japan where he was awarded Doctor of Medicine (M.D) in 1985.[4][5][6] He completed his postgraduate study at the Department of Immunology, Graduate School of Medicine, University of Tokyo, Japan where he was awarded a Ph.D in Immunology supervised by the late Tomio Tada[7][8] in 1989.[9]

Career and research

Furutani-Seiki started his career in 1992, as a postdoc in Janni Nusslein-Volhard's lab at Max-Planck-Institute in Tübingen, he conducted a genome-wide mutagenesis[10] screen using medaka fish as a group leader of the Kondoh Differentiation Signalling ERATO project.[11][12][9]

In 2007, he moved to University of Bath, UK, Centre for Regenerative Medicine [13] as a Medical Research Council Senior Research Fellow and continues his research at Yamaguchi University School of Medicine, Japan.[14][9][15]

Furutani-Seiki research study investigates the molecular mechanisms of mechono-homeostasis in which extracellular mechanical cues are integrated with cell differentiation and proliferation to maintain tissue, organ and body form.[16]

As part of his contribution to the field of Science, Furutani-Seiki discovered a single gene whose product is essential for the body and organs to keep their 3D shape and withstand external forces such as gravity.[17][18] The gene was discovered through the analysis of a medaka fish mutant with a unique flattened phenotype which was identified by the combination of the mutagenesis screen in zebrafish with another screen in medaka fish.[19][10][20][21][22][23] His work further investigates the single cell lineage and regionalisation of cell populations during medaka neurulation.[17][24]

Furutani-Seiki led an international team of researchers from the University of Bath, UK Centre for Regenerative Medicine that identified a gene that helps the body resist gravity and demonstrated what happens when the system goes wrong.[25]

His research contribution covers gravity response, mechanohomeostais, organoid, immunology,[26] cancer,[27] 3D organogenesis,[28] regeneration[29] and developmental genetics;[30] amongst others.[5][31]

Awards and honours

Furutani-Seiki is an alumnus of Kavli Frontiers of Science[32] and a member of the editorial board of Regenerative Medicine Research.[33] He's also a Senior Research Fellow UK of the Medical Research Council (MRC).[9] He's also a professional member of the American Association of Cancer Research[34] and the Molecular Biology Society of Japan.[34]

References

  1. ^ Taniguchi, Masaru (July 1, 2010). "Obituary for Professor Tomio Tada". International Immunology. 22 (7): 541–542. doi:10.1093/intimm/dxq057 – via Silverchair.
  2. ^ "Frühere Forschungsgruppen Entwicklungsbiologie — Institut für Biologie I (Zoologie)". www.bio1.uni-freiburg.de. Retrieved 2022-07-16.
  3. ^ "Makoto Furutani-Seiki | Yamaguchi University | Research contributor in Zebrafish, Hippo signaling pathway". SciSpace - Author. Retrieved 2022-07-15.
  4. ^ "Seiki Makoto - My portal - researchmap". researchmap-jp.translate.goog. Retrieved 2022-07-15.
  5. ^ a b "Makoto Furutani-Seiki". 0-scholar-google-com.brum.beds.ac.uk. Retrieved 2022-07-15.
  6. ^ "NBRP Medaka". shigen.nig.ac.jp. Retrieved 2022-07-16.
  7. ^ Taniguchi, Masaru (2010-07-01). "Obituary for Professor Tomio Tada". International Immunology. 22 (7): 541–542. doi:10.1093/intimm/dxq057. ISSN 0953-8178.
  8. ^ "Mechanical Force Mediated 3D Organogenesis Withstanding Gravity Controlled by YAP - EPFL". memento.epfl.ch. Retrieved 2022-07-16.
  9. ^ a b c d "CDB Symposium 2016". www.cdb.riken.jp. Retrieved 2022-07-15.
  10. ^ a b Taniguchi, Yoshihito; Takeda, Shunichi; Furutani-Seiki, Makoto; Kamei, Yasuhiro; Todo, Takeshi; Sasado, Takao; Deguchi, Tomonori; Kondoh, Hisato; Mudde, Josine; Yamazoe, Mitsuyoshi; Hidaka, Masayuki (2006-12-08). "Generation of medaka gene knockout models by target-selected mutagenesis". Genome Biology. 7 (12): R116. doi:10.1186/gb-2006-7-12-r116. ISSN 1474-760X. PMC 1794429. PMID 17156454.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  11. ^ "Former Groups — Institut für Biologie I (Zoologie)". www.bio1.uni-freiburg.de. Retrieved 2022-07-15.
  12. ^ "ZFIN Person: Furutani-Seiki, Makoto". zfin.org. Retrieved 2022-07-15.
  13. ^ "Protocols and Video Articles Authored by Makoto Furutani-Seiki". www.jove.com. Retrieved 2022-07-15.
  14. ^ "Seiki Makoto - My portal - researchmap". researchmap.jp. Retrieved 2022-07-17.
  15. ^ "Makoto Furutani-Seiki". scholar.google.com. Retrieved 2022-07-15.
  16. ^ Asaoka, Yoichi; Furutani-Seiki, Makoto (2017-12-01). "YAP mediated mechano-homeostasis — conditioning 3D animal body shape". Current Opinion in Cell Biology. Cell Differentiation and Development. 49: 64–70. doi:10.1016/j.ceb.2017.11.013. ISSN 0955-0674.
  17. ^ a b "Single cell lineage and regionalization of cell populations during Medaka neurulation". BioSeek. Retrieved 2022-07-15.
  18. ^ Porazinski, Sean; Wang, Huijia; Asaoka, Yoichi; Behrndt, Martin; Miyamoto, Tatsuo; Morita, Hitoshi; Hata, Shoji; Sasaki, Takashi; Krens, S. F. Gabriel; Osada, Yumi; Asaka, Satoshi (2015-03-16). "YAP is essential for tissue tension to ensure vertebrate 3D body shape". Nature. doi:10.1038/nature14215. ISSN 1476-4687.
  19. ^ Hammerschmidt, M.; Pelegri, F.; Mullins, M.C.; Kane, D.A.; Brand, M.; van Eeden, F.J.; Furutani-Seiki, M.; Granato, M.; Haffter, P.; Heisenberg, C.P.; Jiang, Y.J. (1996-12-01). "Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio". Development. 123 (1): 143–151. doi:10.1242/dev.123.1.143. ISSN 0950-1991.
  20. ^ Haffter, P.; Odenthal, Jörg; Mullins, M. C.; Lin, Shuo; Farrell, Michael J.; Vogelsang, E.; Haas, F.; Brand, M.; van Eeden, Fredericus J. M.; Furutani-Seiki, Makoto; Granato, Michael (1996-11-01). "Mutations affecting pigmentation and shape of the adult zebrafish". Development Genes and Evolution. 206 (4): 260–276. doi:10.1007/s004270050051. ISSN 1432-041X.
  21. ^ Furutani-Seiki, Makoto; Wittbrodt, Joachim (2004-07-01). "Medaka and zebrafish, an evolutionary twin study". Mechanisms of Development. Medaka. 121 (7): 629–637. doi:10.1016/j.mod.2004.05.010. ISSN 0925-4773.
  22. ^ Porazinski, Sean R.; Wang, Huijia; Furutani-Seiki, Makoto (2011). "Essential techniques for introducing medaka to a zebrafish laboratory--towards the combined use of medaka and zebrafish for further genetic dissection of the function of the vertebrate genome". Methods in Molecular Biology (Clifton, N.J.). 770: 211–241. doi:10.1007/978-1-61779-210-6_8. ISSN 1940-6029. PMID 21805266.
  23. ^ Seo, Jungwon; Asaoka, Yoichi; Nagai, Yoko; Hirayama, Jun; Yamasaki, Tokiwa; Namae, Misako; Ohata, Shinya; Shimizu, Nao; Negishi, Takahiro; Kitagawa, Daiju; Kondoh, Hisato (2010-07-01). "Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation". Journal of Cellular Biochemistry. 110 (4): 1022–1037. doi:10.1002/jcb.22616. ISSN 1097-4644. PMID 20564202.
  24. ^ Hirose, Yukihiro; Varga, Zoltan M.; Kondoh, Hisato; Furutani-Seiki, Makoto (2004-06-01). "Single cell lineage and regionalization of cell populations during Medaka neurulation". Development. 131 (11): 2553–2563. doi:10.1242/dev.01140. ISSN 0950-1991.
  25. ^ "Gravity-resisting gene stops our bodies being squashed flat". www.bath.ac.uk. Retrieved 2022-07-15.
  26. ^ Shibata, Kensuke; Shimizu, Takashi; Nakahara, Mashio; Ito, Emi; Legoux, Francois; Fujii, Shotaro; Yamada, Yuka; Furutani-Seiki, Makoto; Lantz, Olivier; Yamasaki, Sho; Watarai, Masahisa (2022-10-01). "The intracellular pathogen Francisella tularensis escapes from adaptive immunity by metabolic adaptation". Life Science Alliance. 5 (10). doi:10.26508/lsa.202201441. ISSN 2575-1077. PMID 35667686.
  27. ^ Kitagawa, Takao; Kobayashi, Daiki; Baron, Byron; Okita, Hajime; Miyamoto, Tatsuo; Takai, Rie; Paudel, Durga; Ohta, Tohru; Asaoka, Yoichi; Tokunaga, Masayuki; Nakagawa, Koji (2022-05-16). "AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma cells": 2022.05.16.492174. doi:10.1101/2022.05.16.492174v1. {{cite journal}}: Cite journal requires |journal= (help)
  28. ^ Furutani-Seiki, Makoto; Sasado, Takao; Morinaga, Chikako; Suwa, Hiroshi; Niwa, Katsutoshi; Yoda, Hiroki; Deguchi, Tomonori; Hirose, Yukihiro; Yasuoka, Akihito; Henrich, Thorsten; Watanabe, Tomomi (July 2004). "A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes". Mechanisms of Development. 121 (7–8): 647–658. doi:10.1016/j.mod.2004.04.016. ISSN 0925-4773. PMID 15210174.
  29. ^ Miyamoto, Tatsuo; Porazinski, Sean; Wang, Huijia; Borovina, Antonia; Ciruna, Brian; Shimizu, Atsushi; Kajii, Tadashi; Kikuchi, Akira; Furutani-Seiki, Makoto; Matsuura, Shinya (2011-05-15). "Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates". Human Molecular Genetics. 20 (10): 2058–2070. doi:10.1093/hmg/ddr090. ISSN 0964-6906.
  30. ^ Brand, M.; Heisenberg, C.P.; Warga, R.M.; Pelegri, F.; Karlstrom, R.O.; Beuchle, D.; Picker, A.; Jiang, Y.J.; Furutani-Seiki, M.; van Eeden, F.J.; Granato, M. (1996-12-01). "Mutations affecting development of the midline and general body shape during zebrafish embryogenesis". Development. 123 (1): 129–142. doi:10.1242/dev.123.1.129. ISSN 0950-1991.
  31. ^ "Makoto Furutani-seiki - Academia.edu". independent.academia.edu. Retrieved 2022-07-16.
  32. ^ "Makoto Furutani-Seiki". www.nasonline.org. Retrieved 2022-07-15.
  33. ^ "Regenerative Medicine Research". www.regenmedres-journal.org. Retrieved 2022-07-15.
  34. ^ a b "清木 誠 (Seiki Makoto) - 米国癌学会 - 所属学協会 - researchmap". researchmap.jp. Retrieved 2022-07-18.
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