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The Metanexus Institute is a not-for-profit organization founded in 1997, “dedicated to promoting scientifically rigorous and philosophically open-ended explorations of foundational questions.”  The institute has organized the exchange of ideas through conferences, and published books. It has worked with hundreds of universities in at least 37 different countries. Metanexus also has an online magazine.
1997 - William Grassie then an assistant professor in the Intellectual Heritage Program at Temple University, launched the “Meta-List,” a moderated listserv on the relationship between religion and science that began with 600 subscribers and quickly grew to several thousand.
1998 - With the help of Peter Dodson, Soloman Katz, Andrew Newberg, and Stephen Dunning, William Grassie created the Philadelphia Center for Religion and Science (PCRS). The goal of the center was to promote literacy in science and religion by hosting seminars, courses, and conferences.
1999 - PCRS hosted a special symposium at the University of Pennsylvania with Holmes Rolston III on the subject of his Gifford Lectures and newly released book Genes, Genesis, and God: Values and Their Origins in Natural and Human History.
2000 - PCRS was renamed the Metanexus Institute, and the Meta-List relaunched as a website with the support of a grant from the John Templeton Foundation, Metanexus then launched the $5.1 million Local Societies Initiative 
2001 - Metanexus administered the $800,000 Templeton Research Lectures program (which awarded grants for interdisciplinary studies and lecture series)  and hosts the “Interpreting Evolution” conference as part of the CTNS Science and Religion Course Program at Haverford College.
2002 - The organization received a $3 million expansion grant from the John Templeton Foundation  and hosted three conferences: “Interpretation Matters” at Haverford College, “Spiritual Transformation Research” at the University of Pennsylvania, “Science and Ultimate Reality” in Princeton, New Jersey. The latter resulting in an edited volume, Science and Ultimate Reality: Quantum Theory, Cosmology, and Complexity. 
2003 - Metanexus launched the $3.3 million Spiritual Transformation Scientific Research Project  and hosted two conferences: “Works of Love: The Science of Altruism” at Villanova University  and “Spiritual Capital” at Harvard University.
2004 - Metanexus launched the $3.75 Spiritual Capital Research Program  and administered the $4.8 million renewal of the Templeton Research Lectures program. The following projects were funded:
- Boston University
- Johns Hopkins University
- Arizona State University
- Stony Brook University
- University of Frankfurt
- University of Pennsylvania
- Vanderbilt University
- University of Arizona
- University of Southern California
- UC – Los Angeles
- University of Montreal
- Stanford University
- Bar Ilian University
- Columbia University
- UC Santa Barbara
2005 - Metanexus launched the $5.79 million Templeton Advanced Research Project  and hosted the “Science and Religion: Global Perspectives” international conference at the University of Pennsylvania.
2006 - Metanexus hosted three conferences: “Continuity and Change” at the University of Pennsylvania, “Spiritual Transformation” at the University of California, Berkeley  and “Amazing Light: Visions for Discovery” (including the Young Researchers Competition) at the University of California, Berkeley  The latter resulted in the publication of an edited volume entitled Visions of Discovery: New Light on Physics, Cosmology, and Consciousness.
2007 - Metanexus launched the $8.9 million Metanexus Global Network Initiative (MGNI) and hosted the “Transdisciplinarity and the Unity of Knowledge” international conference at the University of Pennsylvania. William Grassie stepped down as Executive Director of Metanexus and Eric Weislogel took over managing the Institute.
2009 - Metanxus hosted the “Cosmos, Nature, and Culture” international conference at Arizona State University. Eric Weislogel stepped down as Executive Director and William Grassie returned to manage a reorganization of the Institute.
2010 - Metanexus launched a book series and published three books: Politics by Other Means: Science and Religion in the 21st Century by William Grassie, Advanced Methodologies in the Scientific Study of Religion and Spirituality edited by William Grassie, and Transhumanism and Its Critics edited by Gregory Hansell and William Grassie. William Grassie also wrote a book, The New Sciences of Religion: Exploring Spirituality From the Outside In and the Bottom Up (Palgrave Macmillan). The organization hosted David Christian for lectures on “Big History” at the New York Academy of Sciences, the National Science Foundation, and Villanova University. Metanexus moved its offices to Center City, Philadelphia.
2011 - The board of Metanexus adopted a new mission “promoting scientifically rigorous and philosophically open-ended approaches to foundational questions.”  The organization closed its Philadelphia office and relocated to New York. Metanexus published a new book, Indic Visions in an Age of Science by Varadaraja V. Raman.
Big History 
In recent years, Metanexus Institute has actively promoted the concept of Big History, what is also referred to as the "Epic of Evolution". Big History is a field of historical study that examines history on large scales across long time frames through a multidisciplinary approach, focusing on both the history of the non-human world and on major adaptations and alterations in the human experience. It seeks to understand the integrated history of the cosmos, earth, life, and humanity, using the best available empirical evidence and scholarly methods. It arose as a distinct field in the late 1980s and is related to, but distinct from, world history, as the field examines history from the beginning of time to the present day.
Metanexus Institute has endorsed the adoption of a Big History curriculum in school systems worldwide. It has sought to “incubate such courses in undergraduate colleges and universities, book clubs, religious congregations, and ultimately in age-appropriate ways in K-12 education, here in the United States and around the world.” 
- Grassie, William (2010). Politics by Other Means: Science and Religion in the Twenty-First Century.
- Hansell, Gregory, ed. (2011). H+/- Transhumanism and its Critics.
- Faye Flam, Philadelphia Inquirer, May 9, 1999, “Science, at a High Power/Is God in the Details?”
- David O’Reilly and Melissa Dribben, Philadelphia Inquirer, July 9, 2008, “An Investor in Money and Faith.”
- David O’Reilly, Philadelphia Inquirer, February 18, 2002, “Center thinks religion and science can say much to each other.”
- Christian, David. Maps of Time: An Introduction to Big History.
- Stearns, Peter N. Growing Up: The History of Childhood in a Global Context. p. 9.
- "International Big History Association". Retrieved September 17, 2012.
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