Chopra's early acting career consisted of roles in minor Bollywood films. She appeared in movies such as Time Pass, Red Swastik and Game. She made her Telugu film debut in A film By Aravind. Chopra was also a contestant on Bigg Boss. She was evicted from the show on Day 27.
Sherlyn Chopra at Playboy press meet
In July 2012, Sherlyn Chopra informed media that she would appear on the cover of Playboy magazine. She also shared photos of her with the Playboy founder Hugh Hefner.  She has often been in controversies for posting her naked and semi-naked photos on Twitter.
She has been selected to host the sixth season of MTV Splitsvilla show. In December 2013, she released her music single titled "Bad Girl", Video & Music by Nickk, Rap & Lyrics by Ikka .