NAPSA

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Napsin A aspartic peptidase
Identifiers
Symbols NAPSA ; KAP; Kdap; NAP1; NAPA; SNAPA
External IDs OMIM605631 MGI109365 HomoloGene68418 GeneCards: NAPSA Gene
Orthologs
Species Human Mouse
Entrez 9476 16541
Ensembl ENSG00000131400 ENSMUSG00000002204
UniProt O96009 O09043
RefSeq (mRNA) NM_004851 NM_008437
RefSeq (protein) NP_004842 NP_032463
Location (UCSC) Chr 19:
50.86 – 50.87 Mb
Chr 7:
44.57 – 44.59 Mb
PubMed search [1] [2]

Napsin-A is a protein that in humans is encoded by the NAPSA gene.[1]

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[1]

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