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Nei endonuclease VIII-like 3 (E. coli)
Symbols NEIL3 ; FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3
External IDs OMIM608934 HomoloGene10094 GeneCards: NEIL3 Gene
EC number
Species Human Mouse
Entrez 55247 234258
Ensembl ENSG00000109674 ENSMUSG00000039396
UniProt Q8TAT5 Q8K203
RefSeq (mRNA) NM_018248 NM_146208
RefSeq (protein) NP_060718 NP_666320
Location (UCSC) Chr 4:
178.23 – 178.28 Mb
Chr 8:
53.59 – 53.64 Mb
PubMed search [1] [2]

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.[1]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.[2]


  1. ^ "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)". 
  2. ^ Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.) 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.