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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
External IDs OMIM604495 MGI104752 HomoloGene37631 ChEMBL: 3806 GeneCards: NFKBIB Gene
RNA expression pattern
PBB GE NFKBIB 214062 x at tn.png
PBB GE NFKBIB 214448 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4793 18036
Ensembl ENSG00000104825 ENSMUSG00000030595
UniProt Q15653 Q60778
RefSeq (mRNA) NM_001001716 NM_010908
RefSeq (protein) NP_001230045 NP_035038
Location (UCSC) Chr 19:
39.39 – 39.4 Mb
Chr 7:
28.76 – 28.77 Mb
PubMed search [1] [2]

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.[1]


NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM][2]


NFKBIB has been shown to interact with:


  1. ^ Okamoto T, Ono T, Hori M, Yang JP, Tetsuka T, Kawabe T et al. (November 1998). "Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization". Cytogenet Cell Genet 82 (1–2): 105–6. doi:10.1159/000015077. PMID 9763672. 
  2. ^ "Entrez Gene: NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta". 
  3. ^ Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science 278 (5339): 866–9. doi:10.1126/science.278.5339.866. PMID 9346485. 
  4. ^ Chen Y, Wu J, Ghosh G (June 2003). "KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes". J. Biol. Chem. 278 (25): 23101–6. doi:10.1074/jbc.M301021200. PMID 12672800. 
  5. ^ Suyang H, Phillips R, Douglas I, Ghosh S (October 1996). "Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B". Mol. Cell. Biol. 16 (10): 5444–9. PMC 231544. PMID 8816457. 
  6. ^ Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO et al. (February 1998). "IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells". J. Biol. Chem. 273 (6): 3212–5. doi:10.1074/jbc.273.6.3212. PMID 9452433. 

Further reading[edit]