NGFRAP1

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Nerve growth factor receptor (TNFRSF16) associated protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NGFRAP1 ; BEX3; Bex; DXS6984E; HGR74; NADE
External IDs OMIM300361 MGI1338016 HomoloGene7642 GeneCards: NGFRAP1 Gene
RNA expression pattern
PBB GE NGFRAP1 217963 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27018 12070
Ensembl ENSG00000166681 ENSMUSG00000046432
UniProt Q00994 Q9WTZ9
RefSeq (mRNA) NM_001282674 NM_001110233
RefSeq (protein) NP_001269603 NP_001103703
Location (UCSC) Chr X:
102.63 – 102.63 Mb
Chr X:
136.27 – 136.27 Mb
PubMed search [1] [2]

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.[1][2][3]

Interactions[edit]

NGFRAP1 has been shown to interact with YWHAE[4] and Low affinity nerve growth factor receptor.[1]

References[edit]

  1. ^ a b Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P et al. (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727. 
  2. ^ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M et al. (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. PMID 2171551. 
  3. ^ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1". 
  4. ^ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M et al. (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287. 

Further reading[edit]

  • Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816. 
  • Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
  • Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y et al. (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233. 
  • Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738. 
  • Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M et al. (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287. 
  • Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P et al. (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582. 
  • Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005. 
  • Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455. 
  • Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N et al. (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077. 
  • Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H et al. (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.