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NADPH oxidase, EF-hand calcium binding domain 5
Symbols NOX5 ; MGC149776; MGC149777
External IDs OMIM606572 HomoloGene41568 GeneCards: NOX5 Gene
RNA expression pattern
PBB GE NOX5 220641 at tn.png
More reference expression data
Species Human Mouse
Entrez 79400 n/a
Ensembl ENSG00000255346 n/a
UniProt Q96PH1 n/a
RefSeq (mRNA) NM_001184779 n/a
RefSeq (protein) NP_001171708 n/a
Location (UCSC) Chr 15:
69.22 – 69.36 Mb
PubMed search [1] n/a

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.[1][2]


NOX5 is a novel NADPH oxidase that generates superoxide.[1]

Nox5 interacts with c-abl, superoxide production leads to phosphorylation of c-abl, while inhibition of c-abl kinase activity inhibits Nox5 superoxide production.[3]


  1. ^ a b "Entrez Gene: NOX5 NADPH oxidase, EF-hand calcium binding domain 5". 
  2. ^ Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH (October 2001). "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594–601. doi:10.1074/jbc.M103034200. PMID 11483596. 
  3. ^ El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, Clark RA (March 2008). "NOVEL REDOX-DEPENDENT REGULATION OF NOX5 BY THE TYROSINE KINASE C-ABL". Free Radic. Biol. Med. 44 (5): 868–81. doi:10.1016/j.freeradbiomed.2007.11.020. PMC 2278123. PMID 18160052. 

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