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Nardilysin (N-arginine dibasic convertase)
Symbols NRD1 ; hNRD1; hNRD2
External IDs OMIM602651 MGI1201386 HomoloGene68260 GeneCards: NRD1 Gene
EC number
RNA expression pattern
PBB GE NRD1 208709 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4898 230598
Ensembl ENSG00000078618 ENSMUSG00000053510
UniProt O43847 Q8BHG1
RefSeq (mRNA) NM_001101662 NM_146150
RefSeq (protein) NP_001095132 NP_666262
Location (UCSC) Chr 1:
52.25 – 52.34 Mb
Chr 4:
109 – 109.06 Mb
PubMed search [1] [2]

Nardilysin is a protein that in humans is encoded by the NRD1 gene.[1][2][3]


NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.[4]


  1. ^ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J 327 (3): 773–9. PMC 1218856. PMID 9581555. 
  2. ^ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496. 
  3. ^ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)". 
  4. ^ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. (England) 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822. 

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