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Nuclear transport factor 2
Protein NUTF2 PDB 1a2k.png
PDB rendering based on 1a2k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NUTF2 ; NTF2; PP15
External IDs OMIM605813 MGI1915301 HomoloGene110745 GeneCards: NUTF2 Gene
Species Human Mouse
Entrez 10204 68051
Ensembl ENSG00000102898 ENSMUSG00000008450
UniProt P61970 P61971
RefSeq (mRNA) NM_005796 NM_026532
RefSeq (protein) NP_005787 NP_080808
Location (UCSC) Chr 16:
67.88 – 67.91 Mb
Chr 19:
53.59 – 53.59 Mb
PubMed search [1] [2]

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.[1][2][3]


The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[3]


NUTF2 has been shown to interact with Nucleoporin 62[1][4] and RAN.[5][6]


  1. ^ a b Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498. PMID 7744965. 
  2. ^ Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res 16 (10): 4721–4721. doi:10.1093/nar/16.10.4721. PMC 336660. PMID 3380696. 
  3. ^ a b "Entrez Gene: NUTF2 nuclear transport factor 2". 
  4. ^ Hu T, Guan T, Gerace L (Aug 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840. 
  5. ^ Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS (Nov 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285. 
  6. ^ Stewart M, Kent HM, McCoy AJ (Apr 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885. 

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