NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.
^Correa, R. G., Krajewska, M., Ware, C. F., Gerlic, M., & Reed, J. C. (2014). The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget, 5(6), 1657–1665.
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Correa RG, Ware CF, Reed JC (2014). "NLRs: Sentinels of innate immunity or cancer culprits?". Oncoscience1 (5): 308–9. PMID25594025.