|Headquarters||San Carlos, California|
|Key people||Matthew Rabinowitz (CEO)|
Natera (previously Gene Security Network) is a genetic testing company that operates a CLIA-certified laboratory in San Carlos, California. The company specializes in analyzing microscopic quantities of DNA for reproductive health indications to provide preconception and prenatal genetic testing services primarily to OBGYN physicians and in vitro fertilization centers.
In early 2013, the company launched Panorama, a non-invasive prenatal test for pregnant women that screens for the most common chromosomal anomalies in a fetus as early as nine weeks of gestation. Other services include tests for preimplantation genetic diagnosis (PGD) and miscarriage testing to determine the cause of the loss of the pregnancy. A non-invasive paternity test based on Natera’s technology, was brought to market in August 2011 through a partnership with DNA Diagnostics Center (DDC), which holds a license to the technology in the United States.
Natera launched a non-invasive prenatal test (NIPT) in February 2013 called Panorama that uses an advanced bioinformatics-based algorithm to analyze the cell-free fetal DNA that is found in the mother’s blood. Panorama detects chromosome abnormalities, including Trisomy 21, the cause of Down syndrome, Trisomy 18, the cause of Edwards syndrome, Trisomy 13, the cause of Patau syndrome, sex chromosome abnormalities, triploidy and certain microdeletions as early as the first trimester of pregnancy. In a study published in Human Reproduction, Natera’s technology was shown to be as accurate as metaphase karyotyping, the leading test for detecting chromosomal abnormalities. A clinical study evaluating Natera’s NIPT is funded by the National Institutes of Health and is currently ongoing.
Companies also offering non-invasive prenatal genetic testing include Sequenom, Ariosa, Ravgen, Viaguard Accu-metrics and Verinata Health. Other companies and universities that are working towards developing non-invasive prenatal testing include Stanford University, Fluidigm and Ikonisys.
- Nicolaides, KH; et al. (Oct 10, 2013). "Prenatal detection of fetal triploidy from cell-free DNA testing in maternal blood.". Fetal Diagn Ther. doi:10.1159/000355655. PMID 24135152.
- Nicolaides, KH; et al. (June 2013). "Validation of targeted sequencing of single-nucleotide polymorphism for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X and Y.". Prenat Diag. PMID 23613152.
- Samango-Sprouse, C; et al. (July 2013). "SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy.". Prenat Diag. PMID 23712453.
- Canick, JA; et al. (July 2013). "The impact of maternal fetal plasma DNA fetal fraction on next generation sequencing test for common fetal aneuploidies.". Prenat Diag. PMID 23592541.
- Prenatal testing company Natera raises $20M (San Francisco Business Times)
- One-on-One with Natera founder Jonathan Sheena (San Francisco Business Times)
- Natera Launches Noninvasive Prenatal Test; Quest to Offer in Limited Areas by March, Nationwide in April (GenomeWeb)
- Miscarriage Mysteries Create New Market for Natera (Xconomy)
- GSN Races to Improve Prenatal Tests for Genetic Conditions (Bloomberg)
- Innovator: Matt Rabinowitz Sifts Gene Data for Healthy Pregnancies (BloombergBusinessweek)
- Nicolaides KH, Syngelaki A, Gil MM, Quezada MS, Zinevich Y (October 2013). "Prenatal Detection of Fetal Triploidy from Cell-Free DNA Testing in Maternal Blood". Fetal Diagnosis and Therapy. doi:10.1159/000355655. PMID 24135152.
- Prenatal-screening companies expand scope of DNA tests (Nature)
- Johnson DS, Gemelos G, Baner J, et al. (April 2010). "Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol". Human Reproduction 25 (4): 1066–75. doi:10.1093/humrep/dep452. PMC 2839907. PMID 20100701.
- "Non-invasive prenatal test for Down's syndrome developed". BioNews.